The rough endoplasmatic reticulum is a central nucleation site of siRNA-mediated RNA silencing

Despite progress in mechanistic understanding of the RNA interference (RNAi) pathways, the subcellular sites of RNA silencing remain under debate. Here we show that loading of lipid-transfected siRNAs and endogenous microRNAs (miRNA) into RISC (RNA-induced silencing complexes), encounter of the targ...

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Detalhes bibliográficos
Main Authors: Stalder, Lukas, Heusermann, Wolf, Sokol, Lena, Trojer, Dominic, Wirz, Joel, Hean, Justin, Fritzsche, Anja, Aeschimann, Florian, Pfanzagl, Vera, Basselet, Pascal, Weiler, Jan, Hintersteiner, Martin, Morrissey, David V, Meisner-Kober, Nicole C
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630355/
https://ncbi.nlm.nih.gov/pubmed/23511973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.52
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