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Lifespan Differences in Hematopoietic Stem Cells are Due to Imperfect Repair and Unstable Mean-Reversion

The life-long supply of blood cells depends on the long-term function of hematopoietic stem cells (HSCs). HSCs are functionally defined by their multi-potency and self-renewal capacity. Because of their self-renewal capacity, HSCs were thought to have indefinite lifespans. However, there is increasi...

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Hlavní autoři: Sieburg, Hans B, Cattarossi, Giulio, Muller-Sieburg, Christa E.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3630147/
https://ncbi.nlm.nih.gov/pubmed/23637582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003006
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