Improved Antitumor Activity and Tumor Targeting of NH(2)-Terminal–Specific PEGylated Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand

Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) is considered an attractive anticancer agent due to its tumor cell–specific cytotoxicity. However, its low stability, solubility, unexpected side effects, and weak pharmacokinetic profiles restrict its successful clinical application. T...

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Detalhes bibliográficos
Main Authors: Chae, Su Young, Kim, Tae Hyung, Park, Kyeongsoon, Jin, Cheng-Hao, Son, Sohee, Lee, Seulki, Youn, Yu Seok, Kim, Kwangmeyung, Jo, Dong-Gyu, Kwon, Ick Chan, Chen, Xiaoyuan, Lee, Kang Choon
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629964/
https://ncbi.nlm.nih.gov/pubmed/20515949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-09-1076
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