PEG-transferrin conjugated TRAIL (TNF-related apoptosis-inducing ligand) for therapeutic tumor targeting

Transferrin (Tf) is considered an effective tumor-targeting agent, and PEGylation effectively prolongs in vivo pharmacokinetics by delaying excretion via the renal route. The authors describe the active tumor targeting of long-acting Tf–PEG–TNF-related apoptosis-inducing ligand conjugate (Tf–PEG–TRA...

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Detalhes bibliográficos
Main Authors: Kim, Tae Hyung, Jo, Young Gi, Jiang, Hai Hua, Lim, Sung Mook, Youn, Yu Seok, Lee, Seulki, Chen, Xiaoyuan, Byun, Youngro, Lee, Kang Choon
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629958/
https://ncbi.nlm.nih.gov/pubmed/22824780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2012.07.021
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