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Mechanistic and Structural Determinants of NMDA Receptor Voltage-Dependent Gating and Slow Mg(2+) Unblock
NMDA receptor (NMDAR)-mediated currents depend on membrane depolarization to relieve powerful voltage-dependent NMDAR channel block by external magnesium (Mg(o)(2+)). Mg(o)(2+) unblock from native NMDARs exhibits a fast component that is consistent with rapid Mg(o)(2+)-unbinding kinetics and also a...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Society for Neuroscience
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3629906/ https://ncbi.nlm.nih.gov/pubmed/23447622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3712-12.2013 |
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