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NADPH Oxidase NOX5-S and Nuclear Factor κB1 Mediate Acid-Induced Microsomal Prostaglandin E Synthase-1 Expression in Barrett’s Esophageal Adenocarcinoma Cells
The mechanisms of progression from Barrett’s esophagus (BE) to esophageal adenocarcinoma (EA) are not known. Cycloxygenase-2 (COX-2)-derived prostaglandin E(2) (PGE(2)) has been shown to be important in esophageal tumorigenesis. We have shown that COX-2 mediates acid-induced PGE(2) production. The p...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3629825/ https://ncbi.nlm.nih.gov/pubmed/23439561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.083287 |
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