Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S

Inactivation of tumor suppressor gene p16 may play an important role in the progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EA). Hypermethylation of p16 gene promoter is an important mechanism inactivating p16. However, the mechanisms of p16 hypermethylation in EA are no...

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Autors principals: Hong, Jie, Resnick, Murray, Behar, Jose, Wang, Li Juan, Wands, Jack, DeLellis, Ronald A., Souza, Rhonda F., Spechler, Stuart J., Cao, Weibiao
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2010
Matèries:
Hormones and Signaling
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950676/
https://ncbi.nlm.nih.gov/pubmed/20576920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00186.2010
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