Acid-induced p16 hypermethylation contributes to development of esophageal adenocarcinoma via activation of NADPH oxidase NOX5-S

Inactivation of tumor suppressor gene p16 may play an important role in the progression from Barrett's esophagus (BE) to esophageal adenocarcinoma (EA). Hypermethylation of p16 gene promoter is an important mechanism inactivating p16. However, the mechanisms of p16 hypermethylation in EA are no...

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Bibliografiska uppgifter
Huvudupphovsmän: Hong, Jie, Resnick, Murray, Behar, Jose, Wang, Li Juan, Wands, Jack, DeLellis, Ronald A., Souza, Rhonda F., Spechler, Stuart J., Cao, Weibiao
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Physiological Society 2010
Ämnen:
Hormones and Signaling
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950676/
https://ncbi.nlm.nih.gov/pubmed/20576920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00186.2010
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