Targeting endothelial CD146 attenuates neuroinflammation by limiting lymphocyte extravasation to the CNS

The ability to selectively block the entry of leukocytes into the central nervous system (CNS) without compromising the immune system is an attractive therapeutic approach for treating multiple sclerosis (MS). Using endothelial CD146-deficienct mice as a MS model, we found that endothelial CD146 pla...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Duan, Hongxia, Xing, Shu, Luo, Yongting, Feng, Liqun, Gramaglia, Irene, Zhang, Ying, Lu, Di, Zeng, Qiqun, Fan, Kelong, Feng, Jing, Yang, Dongling, Qin, Zhihai, Couraud, Pierre-Olivier, Romero, Ignacio A., Weksler, Babette, Yan, Xiyun
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629416/
https://ncbi.nlm.nih.gov/pubmed/23595028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01687
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