Crystal Structure of an Anti-Ang2 CrossFab Demonstrates Complete Structural and Functional Integrity of the Variable Domain

Bispecific antibodies are considered as a promising class of future biotherapeutic molecules. They comprise binding specificities for two different antigens, which may provide additive or synergistic modes of action. There is a wide variety of design alternatives for such bispecific antibodies, incl...

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Detalhes bibliográficos
Main Authors: Fenn, Sebastian, Schiller, Christian B., Griese, Julia J., Duerr, Harald, Imhof-Jung, Sabine, Gassner, Christian, Moelleken, Joerg, Regula, Joerg Thomas, Schaefer, Wolfgang, Thomas, Markus, Klein, Christian, Hopfner, Karl-Peter, Kettenberger, Hubert
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629102/
https://ncbi.nlm.nih.gov/pubmed/23613981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061953
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