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Sexually Dimorphic Effects of Catechol-O-Methyltransferase (COMT) Inhibition on Dopamine Metabolism in Multiple Brain Regions

The catechol-O-methyltransferase (COMT) enzyme metabolises catecholamines. COMT inhibitors are licensed for the adjunctive treatment of Parkinson's disease and are attractive therapeutic candidates for other neuropsychiatric conditions. COMT regulates dopamine levels in the prefrontal cortex (P...

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Detalhes bibliográficos
Main Authors: Laatikainen, Linda M., Sharp, Trevor, Harrison, Paul J., Tunbridge, Elizabeth M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3629045/
https://ncbi.nlm.nih.gov/pubmed/23613951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061839
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