Thrombospondin-1 Signaling through CD47 Inhibits Self-renewal by Regulating c-Myc and Other Stem Cell Transcription Factors

Signaling through the thrombospondin-1 receptor CD47 broadly limits cell and tissue survival of stress, but the molecular mechanisms are incompletely understood. We now show that loss of CD47 permits sustained proliferation of primary murine endothelial cells, increases asymmetric division, and enab...

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Autori principali: Kaur, Sukhbir, Soto-Pantoja, David R., Stein, Erica V., Liu, Chengyu, Elkahloun, Abdel G., Pendrak, Michael L., Nicolae, Alina, Singh, Satya P., Nie, Zuqin, Levens, David, Isenberg, Jeffrey S., Roberts, David D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3628113/
https://ncbi.nlm.nih.gov/pubmed/23591719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01673
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