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Mechanism for priming DNA synthesis by yeast DNA Polymerase α
The DNA Polymerase α (Pol α)/primase complex initiates DNA synthesis in eukaryotic replication. In the complex, Pol α and primase cooperate in the production of RNA-DNA oligonucleotides that prime synthesis of new DNA. Here we report crystal structures of the catalytic core of yeast Pol α in unligan...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
eLife Sciences Publications, Ltd
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3628110/ https://ncbi.nlm.nih.gov/pubmed/23599895 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.00482 |
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