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Structures of human primase reveal design of nucleotide elongation site and mode of Pol α tethering
Initiation of DNA synthesis in genomic duplication depends on primase, the DNA-dependent RNA polymerase that synthesizes de novo the oligonucleotides that prime DNA replication. Due to the discontinuous nature of DNA replication, primase activity on the lagging strand is required throughout the repl...
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| Autori principali: | , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2013
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3791718/ https://ncbi.nlm.nih.gov/pubmed/24043831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311185110 |
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