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Lis1 controls dynamics of neuronal filopodia and spines to impact synaptogenesis and social behaviour
LIS1 (PAFAH1B1) mutation can impair neuronal migration, causing lissencephaly in humans. LIS1 loss is associated with dynein protein motor dysfunction, and disrupts the actin cytoskeleton through disregulated RhoGTPases. Recently, LIS1 was implicated as an important protein-network interaction node...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
WILEY-VCH Verlag
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3628102/ https://ncbi.nlm.nih.gov/pubmed/23483716 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202106 |
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