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Diminished Exercise Capacity and Mitochondrial bc1 Complex Deficiency in Tafazzin-Knockdown Mice

The phospholipid, cardiolipin, is essential for maintaining mitochondrial structure and optimal function. Cardiolipin-deficiency in humans, Barth syndrome, is characterized by exercise intolerance, dilated cardiomyopathy, neutropenia, and 3-methyl-glutaconic aciduria. The causative gene is the mitoc...

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Autori principali: Powers, Corey, Huang, Yan, Strauss, Arnold, Khuchua, Zaza
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627988/
https://ncbi.nlm.nih.gov/pubmed/23616771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2013.00074
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