Each of the conserved sequence elements flanking the cleavage site of mammalian histone pre-mRNAs has a distinct role in the 3'-end processing reaction.

To study the substrate requirements for the histone 3'-end processing reaction of mammalian histone pre-mRNAs, we created a set of mutations in the sequences flanking the processing site of a mouse H3 gene. We found that deletion of the downstream purine-rich element hypothesized to interact wi...

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Autores principales: Mowry, K L, Oh, R, Steitz, J A
Formato: Artigo
Lenguaje:Inglês
Publicado: 1989
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC362782/
https://ncbi.nlm.nih.gov/pubmed/2779556
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