Reversible cellular senescence: implications for immortalization of normal human diploid fibroblasts.

IMR-90 normal human diploid fibroblasts, transfected with a steroid inducible mouse mammary tumor virus-driven simian virus 40 T antigen, were carried through crisis to yield an immortal cell line. Growth was dependent on the presence of the inducer (dexamethasone) during both the extended precrisis...

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Publié dans:	Mol Cell Biol
Auteurs principaux:	Wright, W E, Pereira-Smith, O M, Shay, J W
Format:	Artigo
Langue:	Inglês
Publié:	Taylor & Francis 1989
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362778/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2779554/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.7.3088-3092.1989
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