The PARP3- and ATM-dependent phosphorylation of APLF facilitates DNA double-strand break repair

APLF is a forkhead associated-containing protein with poly(ADP-ribose)-binding zinc finger (PBZ) domains, which undergoes ionizing radiation (IR)-induced and Ataxia-Telangiectasia Mutated (ATM)-dependent phosphorylation at serine-116 (Ser(116)). Here, we demonstrate that the phosphorylation of APLF...

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Hlavní autoři: Fenton, Amanda L., Shirodkar, Purnata, Macrae, Chloe J., Meng, Li, Koch, C. Anne
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2013
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627606/
https://ncbi.nlm.nih.gov/pubmed/23449221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt134
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