A v-H-ras-dependent hemopoietic tumor model involving progression from a clonal stage of transformation competence to autocrine interleukin 3 production.

Autocrine interleukin 3 (IL-3)-secreting tumors were generated from an IL-3-dependent mouse mast cell line (PB-3c) after introduction of the v-H-ras oncogene. Tumor progression was characterized by four distinct phenotypes. The first corresponded to immortalized mast cells unresponsive to the oncoge...

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Detalhes bibliográficos
Publicado no:Mol Cell Biol
Main Authors: Nair, A P, Diamantis, I D, Conscience, J F, Kindler, V, Hofer, P, Moroni, C
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 1989
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362709/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2498644/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.3.1183
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