Transforming growth factor alpha: an aromatic side chain at position 38 is essential for biological activity.

Site-directed mutagenesis has been performed in the human transforming growth factor alpha gene. When tyrosine 38 is mutated into phenylalanine or tryptophane, biological activity is retained. In contrast, other alterations between cysteine 34 and cysteine 43 and disruption of disulfide bonds 8 to 2...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Lazar, E, Vicenzi, E, Van Obberghen-Schilling, E, Wolff, B, Dalton, S, Watanabe, S, Sporn, M B
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1989
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362669/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2710128/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.2.860-864.1989
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