Transforming growth factor alpha: an aromatic side chain at position 38 is essential for biological activity.

Site-directed mutagenesis has been performed in the human transforming growth factor alpha gene. When tyrosine 38 is mutated into phenylalanine or tryptophane, biological activity is retained. In contrast, other alterations between cysteine 34 and cysteine 43 and disruption of disulfide bonds 8 to 2...

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Autores principales: Lazar, E, Vicenzi, E, Van Obberghen-Schilling, E, Wolff, B, Dalton, S, Watanabe, S, Sporn, M B
Formato: Artigo
Lenguaje:Inglês
Publicado: 1989
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC362669/
https://ncbi.nlm.nih.gov/pubmed/2710128
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