Individual protein-binding domains of the insulin gene enhancer positively activate beta-cell-specific transcription.

A beta-cell-specific enhancer is located in the 5'-flanking DNA of the rat insulin 1 gene. Two homologous 8-base-pair sequences in the enhancer (IEB1 and IEB2) significantly stimulated transcription from a heterologous promoter (two- to fourfold) in a cell-specific fashion. When the elements were co...

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Библиографические подробности

Опубликовано в::	Mol Cell Biol
Главные авторы:	Karlsson, O, Walker, M D, Rutter, W J, Edlund, T
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Taylor & Francis 1989
Предметы:	Research Article
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362661/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2651906/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.2.823-827.1989
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