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Individual protein-binding domains of the insulin gene enhancer positively activate beta-cell-specific transcription.

A beta-cell-specific enhancer is located in the 5'-flanking DNA of the rat insulin 1 gene. Two homologous 8-base-pair sequences in the enhancer (IEB1 and IEB2) significantly stimulated transcription from a heterologous promoter (two- to fourfold) in a cell-specific fashion. When the elements we...

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Bibliografiske detaljer
Main Authors: Karlsson, O, Walker, M D, Rutter, W J, Edlund, T
Format: Artigo
Sprog:Inglês
Udgivet: 1989
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC362661/
https://ncbi.nlm.nih.gov/pubmed/2651906
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