L450W and Q455K Col8a2 Knock-In Mouse Models of Fuchs Endothelial Corneal Dystrophy Show Distinct Phenotypes and Evidence for Altered Autophagy

PURPOSE. We compared the cellular phenotypes and studied the role of autophagy in the pathogenesis of Fuchs endothelial corneal dystrophy (FECD) using two α2 collagen VIII (Col8a2) knock-in mouse models and human FECD tissues. METHODS. In vivo corneal endothelial cell (CEC) counts and morphology wer...

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Detaylı Bibliyografya
Asıl Yazarlar: Meng, Huan, Matthaei, Mario, Ramanan, Narendrakumar, Grebe, Rhonda, Chakravarti, Shukti, Speck, Caroline L., Kimos, Martha, Vij, Neeraj, Eberhart, Charles G., Jun, Albert S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Association for Research in Vision and Ophthalmology 2013
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626522/
https://ncbi.nlm.nih.gov/pubmed/23422828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-11021
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