L450W and Q455K Col8a2 Knock-In Mouse Models of Fuchs Endothelial Corneal Dystrophy Show Distinct Phenotypes and Evidence for Altered Autophagy

PURPOSE. We compared the cellular phenotypes and studied the role of autophagy in the pathogenesis of Fuchs endothelial corneal dystrophy (FECD) using two α2 collagen VIII (Col8a2) knock-in mouse models and human FECD tissues. METHODS. In vivo corneal endothelial cell (CEC) counts and morphology wer...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
Main Authors: Meng, Huan, Matthaei, Mario, Ramanan, Narendrakumar, Grebe, Rhonda, Chakravarti, Shukti, Speck, Caroline L., Kimos, Martha, Vij, Neeraj, Eberhart, Charles G., Jun, Albert S.
Format: Artigo
Jezik:Inglês
Izdano: The Association for Research in Vision and Ophthalmology 2013
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3626522/
https://ncbi.nlm.nih.gov/pubmed/23422828
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.12-11021
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki