An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis

Fuchs endothelial corneal dystrophy (FECD) is a leading indication for corneal transplantation. FECD is characterized by progressive alterations in endothelial cell morphology, excrescences (guttae) and thickening of the endothelial basement membrane and cell death. Ultimately, these changes lead to...

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Main Authors: Jun, Albert S., Meng, Huan, Ramanan, Naren, Matthaei, Mario, Chakravarti, Shukti, Bonshek, Richard, Black, Graeme C.M., Grebe, Rhonda, Kimos, Martha
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2012
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3276279/
https://ncbi.nlm.nih.gov/pubmed/22002996
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddr473
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