Mapping in vivo topoisomerase I sites on simian virus 40 DNA: asymmetric distribution of sites on replicating molecules.

Complexes between simian virus 40 DNA and topoisomerase I (topo I) were isolated from infected cells treated with camptothecin. The topo I break sites were precisely mapped by primer extension from defined oligonucleotides. Of the 56 sites, 40 conform to the in vitro consensus sequence previously de...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Porter, S E, Champoux, J J
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1989
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC362630/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2540421/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.9.2.541-550.1989
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