FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4

Toll-like receptor 4 (TLR4) plays a pivotal role in innate immune responses, and the transcription factor CCAAT/enhancer binding protein delta (C/EBPδ, Cebpd) is a TLR4-induced gene. Here, we identify a positive feedback loop in which C/EBPδ activates Tlr4 gene expression in macrophages and tumour c...

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Hauptverfasser: Balamurugan, Kuppusamy, Sharan, Shikha, Klarmann, Kimberly D., Zhang, Youhong, Coppola, Vincenzo, Summers, Glenn H., Roger, Thierry, Morrison, Deborah K., Keller, Jonathan R., Sterneck, Esta
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625980/
https://ncbi.nlm.nih.gov/pubmed/23575666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2677
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