EZH2 Oncogenic Activity in Castration Resistant Prostate Cancer Cells is Polycomb-Independent

Epigenetic regulators represent a promising new class of therapeutic targets for cancer. Enhancer of zeste homolog 2 (EZH2), a subunit of Polycomb repressive complex 2 (PRC2), silences gene expression via its histone methyltransferase activity. Here we report that the oncogenic function of EZH2 in c...

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Huvudupphovsmän: Xu, Kexin, Wu, Zhenhua Jeremy, Groner, Anna C., He, Housheng Hansen, Cai, Changmeng, Lis, Rosina T., Wu, Xiaoqiu, Stack, Edward C., Loda, Massimo, Liu, Tao, Xu, Han, Cato, Laura, Thornton, James E., Gregory, Richard I., Morrissey, Colm, Vessella, Robert L., Montironi, Rodolfo, Magi-Galluzzi, Cristina, Kantoff, Philip W., Balk, Steven P., Liu, X. Shirley, Brown, Myles
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625962/
https://ncbi.nlm.nih.gov/pubmed/23239736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1227604
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