Polycomb subunits Ezh1 and Ezh2 regulate the Merkel cell differentiation program in skin stem cells

While the Polycomb complex is known to regulate cell identity in ES cells, its role in controlling tissue-specific stem cells is not well understood. Here we show that removal of Ezh1 and Ezh2, key Polycomb subunits, from mouse skin results in a marked change in fate determination in epidermal proge...

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Bibliographic Details
Main Authors: Bardot, Evan S, Valdes, Victor J, Zhang, Jisheng, Perdigoto, Carolina N, Nicolis, Silvia, Hearn, Stephen A, Silva, Jose M, Ezhkova, Elena
Format: Artigo
Language:Inglês
Published: European Molecular Biology Organization 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715854/
https://ncbi.nlm.nih.gov/pubmed/23673358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.110
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