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Glutathione oxidation unmasks proarrhythmic vulnerability of chronically hyperglycemic guinea pigs

Chronic hyperglycemia in type-1 diabetes mellitus is associated with oxidative stress (OS) and sudden death. Mechanistic links remain unclear. We investigated changes in electrophysiological (EP) properties in a model of chronic hyperglycemia before and after challenge with OS by GSH oxidation and t...

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Bibliografske podrobnosti
Main Authors: Xie, Chaoqin, Biary, Nora, Tocchetti, Carlo G., Aon, Miguel A., Paolocci, Nazareno, Kauffman, Justin, Akar, Fadi G.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625895/
https://ncbi.nlm.nih.gov/pubmed/23376824
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00026.2012
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