Functional crosstalk between the mitochondrial PTP and K(ATP) channels determine arrhythmic vulnerability to oxidative stress

Background: Mitochondrial permeability transition pore (mPTP) opening is a terminal event leading to mitochondrial dysfunction and cell death under conditions of oxidative stress (OS). However, mPTP blockade with cyclosporine A (CsA) has shown variable efficacy in limiting post-ischemic dysfunction...

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Bibliographic Details
Main Authors: Xie, Chaoqin, Kauffman, Justin, Akar, Fadi G.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4099963/
https://ncbi.nlm.nih.gov/pubmed/25076913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00264
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