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Functional crosstalk between the mitochondrial PTP and K(ATP) channels determine arrhythmic vulnerability to oxidative stress
Background: Mitochondrial permeability transition pore (mPTP) opening is a terminal event leading to mitochondrial dysfunction and cell death under conditions of oxidative stress (OS). However, mPTP blockade with cyclosporine A (CsA) has shown variable efficacy in limiting post-ischemic dysfunction...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4099963/ https://ncbi.nlm.nih.gov/pubmed/25076913 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00264 |
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