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The Role of Protonation States in Ligand-Receptor Recognition and Binding

In this review we discuss the role of protonation states in receptor-ligand interactions, providing experimental evidences and computational predictions that complex formation may involve titratable groups with unusual pKa’s and that protonation states frequently change from unbound to bound states....

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Hlavní autoři: Petukh, Marharyta, Stefl, Shannon, Alexov, Emil
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625499/
https://ncbi.nlm.nih.gov/pubmed/23170880
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