A Small-molecule Inhibitor, 5′-O-Tritylthymidine, targets FAK and Mdm-2 Interaction, and Blocks Breast and Colon Tumorigenesis in vivo

Lignende værker

• Mitoxantrone Targets the ATP-binding Site of FAK, Binds the FAK Kinase Domain and Decreases FAK, Pyk-2, c-Src, and IGF-1R, In Vitro Kinase Activities
  af: Golubovskaya, Vita, et al.
  Udgivet: (2013)
• Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth
  af: Golubovskaya, Vita M, et al.
  Udgivet: (2013)
• Nanog Increases Focal Adhesion Kinase (FAK) Promoter Activity and Expression and Directly Binds to FAK Protein to Be Phosphorylated
  af: Ho, Baotran, et al.
  Udgivet: (2012)
• A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.1(3,7)]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo
  af: Golubovskaya, Vita M., et al.
  Udgivet: (2012)
• A novel small molecule inhibitor of FAK decreases growth of human pancreatic cancer
  af: Hochwald, Steven N., et al.
  Udgivet: (2009)