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Nanog Increases Focal Adhesion Kinase (FAK) Promoter Activity and Expression and Directly Binds to FAK Protein to Be Phosphorylated

Nanog and FAK were shown to be overexpressed in cancer cells. In this report, the Nanog overexpression increased FAK expression in 293, SW480, and SW620 cancer cells. Nanog binds the FAK promoter and up-regulates its activity, whereas Nanog siRNA decreases FAK promoter activity and FAK mRNA. The FAK...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Ho, Baotran, Olson, Gretchen, Figel, Sheila, Gelman, Irwin, Cance, William G., Golubovskaya, Vita M.
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2012
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365765/
https://ncbi.nlm.nih.gov/pubmed/22493428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.322883
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