Nanog Increases Focal Adhesion Kinase (FAK) Promoter Activity and Expression and Directly Binds to FAK Protein to Be Phosphorylated

Nanog and FAK were shown to be overexpressed in cancer cells. In this report, the Nanog overexpression increased FAK expression in 293, SW480, and SW620 cancer cells. Nanog binds the FAK promoter and up-regulates its activity, whereas Nanog siRNA decreases FAK promoter activity and FAK mRNA. The FAK...

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Detalhes bibliográficos
Main Authors: Ho, Baotran, Olson, Gretchen, Figel, Sheila, Gelman, Irwin, Cance, William G., Golubovskaya, Vita M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365765/
https://ncbi.nlm.nih.gov/pubmed/22493428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.322883
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