Nanog Increases Focal Adhesion Kinase (FAK) Promoter Activity and Expression and Directly Binds to FAK Protein to Be Phosphorylated

Nanog and FAK were shown to be overexpressed in cancer cells. In this report, the Nanog overexpression increased FAK expression in 293, SW480, and SW620 cancer cells. Nanog binds the FAK promoter and up-regulates its activity, whereas Nanog siRNA decreases FAK promoter activity and FAK mRNA. The FAK...

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Main Authors: Ho, Baotran, Olson, Gretchen, Figel, Sheila, Gelman, Irwin, Cance, William G., Golubovskaya, Vita M.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2012
Ábhair:
Signal Transduction
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365765/
https://ncbi.nlm.nih.gov/pubmed/22493428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.322883
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