Protein Binding of Lopinavir and Ritonavir During Four Phases of Pregnancy: Implications for Treatment Guidelines

OBJECTIVE: To investigate the intraindividual pharmacokinetics of total (protein bound + unbound) and unbound lopinavir/ritonavir (LPV/RTV) and to assess whether the pediatric formulation (100mg/25mg) can overcome any pregnancy-associated changes. DESIGN: Prospective longitudinal pharmacokinetic (PK...

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Bibliografiset tiedot
Päätekijät: Patterson, Kristine B., Dumond, Julie B., Prince, Heather A., Jenkins, Amanda J., Scarsi, Kimberly K., Wang, Ruili, Malone, Stephanie, Hudgens, Michael G., Kashuba, Angela DM.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2013
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625477/
https://ncbi.nlm.nih.gov/pubmed/23221983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAI.0b013e31827fd47e
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