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Fine-Tuning S1P Therapeutics
Sphingosine 1-phosphate receptor-1 (S1P(1)), a novel therapeutic target for multiple sclerosis, regulates lymphocyte trafficking, heart rate, and vascular function. The discovery of NIBR-0213, a competitive antagonist for S1P(1) that inhibits autoimmune inflammation while sparing bradycardia (Quanca...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3625427/ https://ncbi.nlm.nih.gov/pubmed/22999874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.09.002 |
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