Robo4 Cooperates with Cxcr4 to Specify Hematopoietic Stem Cell Localization to Bone Marrow Niches

Specific bone marrow (BM) niches are critical for hematopoietic stem cell (HSC) function during both normal hematopoiesis and in stem cell transplantation therapy. We demonstrate that the guidance molecule Robo4 functions to specifically anchor HSCs to BM niches. Robo4-deficient HSCs displayed poor...

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Autores principales: Smith-Berdan, Stephanie, Nguyen, Andrew, Hassanein, Deena, Zimmer, Matthew, Ugarte, Fernando, Ciriza, Jesús, Li, Dean, García-Ojeda, Marcos E., Hinck, Lindsay, Forsberg, E. Camilla
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625377/
https://ncbi.nlm.nih.gov/pubmed/21211783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2010.11.030
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