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Transcriptional data: a new gateway to drug repositioning?

Recent advances in computational biology suggest that any perturbation to the transcriptional programme of the cell can be summarised by a proper ‘signature’: a set of genes combined with a pattern of expression. Therefore, it should be possible to generate proxies of clinicopathological phenotypes...

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Détails bibliographiques
Auteurs principaux: Iorio, Francesco, Rittman, Timothy, Ge, Hong, Menden, Michael, Saez-Rodriguez, Julio
Format: Artigo
Langue:Inglês
Publié: Elsevier Science Ltd. ;, Distributed by Virgin Mailing and Distribution 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3625109/
https://ncbi.nlm.nih.gov/pubmed/22897878
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.drudis.2012.07.014
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