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Discovery of drug mode of action and drug repositioning from transcriptional responses
A bottleneck in drug discovery is the identification of the molecular targets of a compound (mode of action, MoA) and of its off-target effects. Previous approaches to elucidate drug MoA include analysis of chemical structures, transcriptional responses following treatment, and text mining. Methods...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2010
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2930479/ https://ncbi.nlm.nih.gov/pubmed/20679242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000138107 |
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