Discovery of drug mode of action and drug repositioning from transcriptional responses

A bottleneck in drug discovery is the identification of the molecular targets of a compound (mode of action, MoA) and of its off-target effects. Previous approaches to elucidate drug MoA include analysis of chemical structures, transcriptional responses following treatment, and text mining. Methods...

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Bibliografiska uppgifter
Huvudupphovsmän: Iorio, Francesco, Bosotti, Roberta, Scacheri, Emanuela, Belcastro, Vincenzo, Mithbaokar, Pratibha, Ferriero, Rosa, Murino, Loredana, Tagliaferri, Roberto, Brunetti-Pierri, Nicola, Isacchi, Antonella, di Bernardo, Diego
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2010
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2930479/
https://ncbi.nlm.nih.gov/pubmed/20679242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1000138107
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