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High incidence of antibodies to protamine and protamine/heparin complexes in patients undergoing cardiopulmonary bypass
Protamine is routinely used to reverse heparin anticoagulation during cardiopulmonary bypass (CPB). Heparin interacts with protamine to form ultralarge complexes that are immunogenic in mice. We hypothesized that patients exposed to protamine and heparin during CPB will develop antibodies (Abs) to p...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society of Hematology
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3624931/ https://ncbi.nlm.nih.gov/pubmed/23422751 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-11-469130 |
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