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High incidence of antibodies to protamine and protamine/heparin complexes in patients undergoing cardiopulmonary bypass

Protamine is routinely used to reverse heparin anticoagulation during cardiopulmonary bypass (CPB). Heparin interacts with protamine to form ultralarge complexes that are immunogenic in mice. We hypothesized that patients exposed to protamine and heparin during CPB will develop antibodies (Abs) to p...

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Detalhes bibliográficos
Main Authors: Lee, Grace M., Welsby, Ian J., Phillips-Bute, Barbara, Ortel, Thomas L., Arepally, Gowthami M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624931/
https://ncbi.nlm.nih.gov/pubmed/23422751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-11-469130
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