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Co-induction of the heat shock response ameliorates disease progression in a mouse model of human spinal and bulbar muscular atrophy: implications for therapy

Spinal and bulbar muscular atrophy, also known as Kennedy’s disease, is an adult-onset hereditary neurodegenerative disorder caused by an expansion of the polyglutamine repeat in the first exon in the androgen receptor gene. Pathologically, the disease is defined by selective loss of spinal and bulb...

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Bibliografische gegevens
Hoofdauteurs: Malik, Bilal, Nirmalananthan, Niranjanan, Gray, Anna L., La Spada, Albert R., Hanna, Michael G., Greensmith, Linda
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2013
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624668/
https://ncbi.nlm.nih.gov/pubmed/23393146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/aws343
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