Mutational Tail Loss Is an Evolutionary Mechanism for Liberating Marapsins and Other Type I Serine Proteases from Transmembrane Anchors

Human and mouse marapsins (Prss27) are serine proteases preferentially expressed by stratified squamous epithelia. However, mouse marapsin contains a transmembrane anchor absent from the human enzyme. To gain insights into physical forms, activities, inhibition, and roles in epithelial differentiati...

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Bibliographic Details
Main Authors: Raman, Kavita, Trivedi, Neil N., Raymond, Wilfred W., Ganesan, Rajkumar, Kirchhofer, Daniel, Verghese, George M., Craik, Charles S., Schneider, Eric L., Nimishakavi, Shilpa, Caughey, George H.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Enzymology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624440/
https://ncbi.nlm.nih.gov/pubmed/23447538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.449033
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