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Systematic Proteomic Analysis Identifies β-Site Amyloid Precursor Protein Cleaving Enzyme 2 and 1 (BACE2 and BACE1) Substrates in Pancreatic β-Cells

Expansion of functional islet β-cell mass is a physiological process to compensate for increased insulin demand. Deficiency or pharmacological inhibition of the plasma membrane protease BACE2 enhances pancreatic β-cell function and proliferation, and therefore BACE2 is a putative target for the ther...

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Sonraí Bibleagrafaíochta
Main Authors: Stützer, Ina, Selevsek, Nathalie, Esterházy, Daria, Schmidt, Alexander, Aebersold, Ruedi, Stoffel, Markus
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624435/
https://ncbi.nlm.nih.gov/pubmed/23430253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.444703
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