Large Scale Structural Rearrangement of a Serine Hydrolase from Francisella tularensis Facilitates Catalysis

Tularemia is a deadly, febrile disease caused by infection by the Gram-negative bacterium, Francisella tularensis. Members of the ubiquitous serine hydrolase protein family are among current targets to treat diverse bacterial infections. Herein we present a structural and functional study of a novel...

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Bibliografski detalji
Glavni autori: Filippova, Ekaterina V., Weston, Leigh A., Kuhn, Misty L., Geissler, Brett, Gehring, Alexandra M., Armoush, Nicola, Adkins, Chinessa T., Minasov, George, Dubrovska, Ievgeniia, Shuvalova, Ludmilla, Winsor, James R., Lavis, Luke D., Satchell, Karla J. F., Becker, Daniel P., Anderson, Wayne F., Johnson, R. Jeremy
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Protein Structure and Folding
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624434/
https://ncbi.nlm.nih.gov/pubmed/23430251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446625
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