Large Scale Structural Rearrangement of a Serine Hydrolase from Francisella tularensis Facilitates Catalysis

Tularemia is a deadly, febrile disease caused by infection by the Gram-negative bacterium, Francisella tularensis. Members of the ubiquitous serine hydrolase protein family are among current targets to treat diverse bacterial infections. Herein we present a structural and functional study of a novel...

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Detaylı Bibliyografya
Asıl Yazarlar: Filippova, Ekaterina V., Weston, Leigh A., Kuhn, Misty L., Geissler, Brett, Gehring, Alexandra M., Armoush, Nicola, Adkins, Chinessa T., Minasov, George, Dubrovska, Ievgeniia, Shuvalova, Ludmilla, Winsor, James R., Lavis, Luke D., Satchell, Karla J. F., Becker, Daniel P., Anderson, Wayne F., Johnson, R. Jeremy
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2013
Konular:
Protein Structure and Folding
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624434/
https://ncbi.nlm.nih.gov/pubmed/23430251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446625
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