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Large Scale Structural Rearrangement of a Serine Hydrolase from Francisella tularensis Facilitates Catalysis

Tularemia is a deadly, febrile disease caused by infection by the Gram-negative bacterium, Francisella tularensis. Members of the ubiquitous serine hydrolase protein family are among current targets to treat diverse bacterial infections. Herein we present a structural and functional study of a novel...

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Библиографические подробности
Главные авторы: Filippova, Ekaterina V., Weston, Leigh A., Kuhn, Misty L., Geissler, Brett, Gehring, Alexandra M., Armoush, Nicola, Adkins, Chinessa T., Minasov, George, Dubrovska, Ievgeniia, Shuvalova, Ludmilla, Winsor, James R., Lavis, Luke D., Satchell, Karla J. F., Becker, Daniel P., Anderson, Wayne F., Johnson, R. Jeremy
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3624434/
https://ncbi.nlm.nih.gov/pubmed/23430251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.446625
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